Endometrial Cancer Management

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 Endometrial Cancer Managaement

Risk Factors
  • Tamoxifen
  • Postmenopausal > Premenopausal
  • Obesity(Because of high estrogen)
  • Sedentary lifestyle
  • Diabetes Mellitus
  • Early Menarche
  • Late Menopause
  • Unopped form of Estrogen containing HRT
Types of Endometrial Cancer
  • Pure Sarcoma
  • Malignant Mixed Mullerain Tumor
  • Endometroid Adenocarcinoma
Most common type is endometroid adenocarcinoma which accounts for about 60% cases of endometrial carcinoma.
Trials for the management of Endometrial Cancer
  • ASTEC Trial
  • PROTEC Trial
Investigations of Endometrial Cancer
  • Transvaginal Ultrasound ( First line)
  • Endometrial Biopsy (Pipelle , hysteroscopy , diagnostic DnC etc)
  • Histopathology ( To check for hyperplasia with atypia and hyperplasia without atypia)
  • MRI is done for stagging and invasion of metastasis.
With what endometrial thickness will we take biopsy for diagnosing Endometrial Cancer
Endometrial thickness cut off of 4 mm or more should be investigated as recommended by British Gynaecological Cancer Society.

Recurrence of Endometrial Cancer
  • Most common site of Relapse :- 
  • Vaginal Vault .
  • If previous Surgery only :- 
  • Radiotherapy is the treatment.

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